Dna2 offers support for stalled forks.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22682239.
- Also identified by DOI 10.1016/j.cell.2012.05.021.
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Abstract
The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing the reversal of stalled and terminal replication forks. Hu et al. now show that the ATR pathway targets the Dna2 nuclease to process stalled forks and counteract fork reversal.