Target practice: modeling tumors with stem cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 22682241.
- Also identified by DOI 10.1016/j.cell.2012.05.019.
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Abstract
A variant neoplastic line of human pluripotent stem cell (hPSC) displays unique tumorigenic properties, including enhanced self-renewal and survival, and aberrant blockade in differentiation. Sachlos et al. adopted a neoplastic hPSC differentiation platform to screen small molecules that selectively induce differentiation of cancer stem cells.