Wnt/β-catenin signaling and disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22682243.
- Also identified by DOI 10.1016/j.cell.2012.05.012.
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Abstract
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
Medical subject headings
- Wnt Proteins
- Wnt Signaling Pathway
- beta Catenin