Biology of human papillomavirus-related oropharyngeal cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22687942.
- Also identified by DOI 10.1016/j.semradonc.2012.03.002 and PMC identifier 3715056.
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Abstract
Recent data show that human papillomavirus-positive oropharyngeal cancer (OPC) has a distinct biological and clinical behavior compared with human papillomavirus-negative OPC. As this subset of head and neck cancer represents an increasing public health concern, a thorough understanding of the causative and mechanistic differences between these diseases and how these distinctions impact clinical treatment is required. In this review, we will summarize recent data in epidemiology, the mechanism of viral carcinogenesis and differences in tumor biology that may provide insights to improve the clinical management of patients with human papillomavirus-positive OPC.
Medical subject headings
- Oropharyngeal Neoplasms
- Papillomavirus Infections