Cobalt from metal-on-metal hip replacements may be the clinically relevant active agent responsible for periprosthetic tissue reactions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22688088.
- Also identified by DOI 10.1016/j.actbio.2012.05.003.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Some types of metal-on-metal (MOM) hip replacements have unacceptably high rates of failure, such as the Ultima TPS MOM hip, with 13.8% failure at 5 years. This has been attributed to an inflammatory reaction following the release of cobalt (Co) and chromium (Cr) from the bearing surfaces and modular junctions. There is in vitro evidence that Co is more important than Cr in the inflammatory process, but there are no reported human tissue studies of the analysis of implant-derived metals.
Medical subject headings
- Arthroplasty, Replacement, Hip
- Cobalt
- Hip Joint
- Hip Prosthesis
- Metal-on-Metal Joint Prostheses