Multilead measurement system for the time-domain analysis of bioimpedance magnitude.

Abstract

Bioimpedance measurement applications range from the characterization of organic matter to the monitoring of biological signals and physiological parameters. Occasionally, multiple bioimpedances measured in different locations are combined in order to solve complex problems or produce enhanced physiological measures. The present multilead bioimpedance measurement methods are mainly focused on electrical impedance tomography. Systems designed to suit other multilead applications are lacking. In this study, a novel multilead bioimpedance measurement system was designed. This was particularly aimed at the time-domain analysis of bioimpedance magnitude. Frequency division multiplexing was used to avoid overlapping between excitation signals; undersampling, to reduce the hardware requirements; and power isolated active current sources, to reduce the electrical interactions between leads. These theoretical concepts were implemented on a prototype device. The prototype was tested on equivalent circuits and a saline tank in order to assess excitation signal interferences and electrical interactions between leads. The results showed that the proposed techniques are functional and the system's validity was demonstrated on a real application, multilead impedance pneumography. Potential applications and further improvements were discussed. It was concluded that the novel approach potentially enables accurate and relatively low-power multilead bioimpedance measurements systems.