Bioavailable vitamin D in chronic kidney disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22699377.
- Also identified by DOI 10.1038/ki.2012.135.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.
Medical subject headings
- Bone Remodeling
- Bone and Bones
- Kidney Failure, Chronic
- Renal Dialysis
- Vitamin D
- Vitamin D Deficiency