Hematopoietic stem cell heterogeneity takes center stage.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22704509.
- Also identified by DOI 10.1016/j.stem.2012.05.006.
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Abstract
Over the past 10 years, increasing evidence has accumulated that heterogeneity is a feature of hematopoietic stem cell (HSC) proliferation, self-renewal, and differentiation based on examination of these properties at a clonal level. The heterogeneous behavior of HSCs reflects the operation of a complex interplay of intrinsic and extrinsic variables. In this review, we discuss key findings from the last 5 years that reveal new insights into the mechanisms involved.
Medical subject headings
- Cell Differentiation
- Clone Cells
- Hematopoietic Stem Cell Transplantation
- Hematopoietic Stem Cells
- Neoplasms