Germline stem cells: origin and destiny.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22704513.
- Also identified by DOI 10.1016/j.stem.2012.05.016 and PMC identifier 3750984.
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Abstract
Germline stem cells are key to genome transmission to future generations. Over recent years, there have been numerous insights into the regulatory mechanisms that govern both germ cell specification and the maintenance of the germline in adults. Complex regulatory interactions with both the niche and the environment modulate germline stem cell function. This perspective highlights some examples of this regulation to illustrate the diversity and complexity of the mechanisms involved.
Medical subject headings
- Germ Cells
- Stem Cell Niche
- Stem Cells