A Peptide-Based Material for Therapeutic Carbon Monoxide Delivery.
basic_science · Level V
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- Record sourced from PubMed, PMID 22707978.
- Also identified by PMC identifier 3374652.
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Abstract
We report on the preparation of the first material for therapeutic delivery of CO. A peptide amphiphile was synthesized with a covalently attached ruthenium tricarbonyl. Self-assembled nanofiber gels containing this peptide spontaneously released CO with prolonged release kinetics compared to soluble CO donors. Oxidatively stressed cardiomyocytes had improved viability when treated with this peptide, demonstrating its potential as a biodegradable gel for localized therapeutic CO delivery.