Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network.

Bellan, Leon M; Kniazeva, Tatiana; Kim, Ernest S; Epshteyn, Alla A; Cropek, Donald M; Langer, Robert; Borenstein, Jeffrey T · Adv Healthc Mater · 2012

basic_science · Level V

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Abstract

A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels.

Medical subject headings