Weakly charged cationic nanoparticles induce DNA bending and strand separation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22711427.
- Also identified by DOI 10.1002/adma.201104891.
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Abstract
Weakly charged cationic nanoparticles cause structural changes including local denaturing and compaction to DNA under mild conditions. The charged ligands bind to the phosphate backbone of DNA and the uncharged ligands penetrate the helix and disrupt base pairing. Mobility shifts in electrophoresis, molecular dynamics, and UV-vis spectrophotometry give clues to the details of the interactions.
Medical subject headings
- DNA
- Nanoparticles