Mosaic hydrogels: one-step formation of multiscale soft materials.

Leng, Lian; McAllister, Arianna; Zhang, Boyang; Radisic, Milica; Günther, Axel · Adv Mater · 2012

basic_science · Level V

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Abstract

The one-step, continuous formation of mosaic hydrogel sheets is presented. A microfluidic device allows controllable incorporation of secondary biopolymers within a flowing biopolymer sheet followed by a cross-linking step that retains the microscale composition. Information is encoded; mosaic stiffness and diffusivity patterns are created; tessellations are populated with biomolecules, microparticles and viable primary cells; and 3D soft material assemblies are demonstrated.

Medical subject headings