DNA hypermethylation and 1p Loss silence NHE-1 in oligodendroglioma.
basic_science · Level V
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- Record sourced from PubMed, PMID 22718548.
- Also identified by DOI 10.1002/ana.23610.
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Abstract
Oligodendroglioma is characterized by mutations of IDH and CIC, 1p/19q loss, and slow growth. We found that NHE-1 on 1p is silenced in oligodendrogliomas secondary to IDH-associated hypermethylation and 1p allelic loss. Silencing lowers intracellular pH and attenuates acid load recovery in oligodendroglioma cells. Others have shown that rapid tumor growth cannot occur without NHE-1-mediated neutralization of the acidosis generated by the Warburg glycolytic shift. Our findings show for the first time that the pH regulator NHE-1 can be silenced in a human cancer and also suggest that pH deregulation may contribute to the distinctive biology of human oligodendroglioma.
Medical subject headings
- Brain Neoplasms
- Chromosome Deletion
- Chromosomes, Human, Pair 1
- DNA Methylation
- Mutation
- Oligodendroglioma
- Sodium-Hydrogen Exchangers