Assessing cell and organ senescence biomarkers.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22723221.
- Also identified by DOI 10.1161/CIRCRESAHA.111.247866 and PMC identifier 4824275.
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Abstract
A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of several senescence biomarkers.
Medical subject headings
- Aging
- Biomarkers
- Cellular Senescence