Resurrecting DNAzymes as sequence-specific therapeutics.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 22723461.
- Also identified by DOI 10.1126/scitranslmed.3004080.
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Abstract
In a mouse model of skin cancer, intratumoral injection of a sequence-specific mRNA-cleaving DNA enzyme caused potent inhibition of tumor growth and unusually benign pharmacodynamic profiles.
Medical subject headings
- DNA, Catalytic
- Proto-Oncogene Proteins c-jun
- Skin Neoplasms