Membrane protein structure predictions for exploration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22726429.
- Also identified by DOI 10.1016/j.cell.2012.06.004 and PMC identifier 3688449.
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Abstract
A daring experiment is performed. Using sequence alignments to predict contacts between residues in protein spatial structures, Hopf et al. are publishing untested de novo structure models for 11 transmembrane protein families. Will their models stand the test of time and hold up to experimentation? The prospects are excellent.