Tiki casts a spell on Wnt.
editorial · Level V
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- Record sourced from PubMed, PMID 22726430.
- Also identified by DOI 10.1016/j.cell.2012.06.007.
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Abstract
Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself.