A movie of RNA polymerase II transcription.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22726432.
- Also identified by DOI 10.1016/j.cell.2012.06.006.
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Abstract
We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.
Medical subject headings
- RNA Polymerase II
- Transcription, Genetic