RNA polymerase backtracking in gene regulation and genome instability.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22726433.
- Also identified by DOI 10.1016/j.cell.2012.06.003 and PMC identifier 3815583.
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Abstract
RNA polymerase is a ratchet machine that oscillates between productive and backtracked states at numerous DNA positions. Since its first description 15 years ago, backtracking--the reversible sliding of RNA polymerase along DNA and RNA--has been implicated in many critical processes in bacteria and eukaryotes, including the control of transcription elongation, pausing, termination, fidelity, and genome instability.
Medical subject headings
- Bacteria
- DNA-Directed RNA Polymerases
- Transcription, Genetic