Lighting the fat furnace without SFRP5.
Level V
Where this comes from
- Record sourced from PubMed, PMID 22728932.
- Also identified by DOI 10.1172/JCI64196 and PMC identifier 3386836.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
WNT signaling plays a central role in the regulation of cellular growth and differentiation. In this issue of the JCI, Mori et al. link WNT signaling to the oxidative capacity of adipocytes during obesity. They show that secreted frizzled-related protein 5 is an extracellular matrix-residing protein that is highly induced during obesity and inhibits oxidative phosphorylation in a tissue-autonomous manner, possibly by sequestering WNT3a. These results implicate local WNT signaling as an attractive target for combating obesity.
Medical subject headings
- Adipocytes
- Intercellular Signaling Peptides and Proteins
- Mitochondria
- Obesity
- Wnt Signaling Pathway