Severe sepsis, coagulation, and fibrinolysis: dead end or one way?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22732284.
- Also identified by DOI 10.1097/CCM.0b013e318258ff30.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
It was suggested more than 30 yrs ago that inhibition of the clotting cascade by natural anticoagulants could decrease the high mortality observed in patients suffering from severe sepsis and septic shock. Unfortunately, this therapeutic "paradigm" has led to a dead end, illustrated by the failure of all randomized trials and the recent withdrawal of recombinant activated protein C. Should we now definitely give up trying to treat septic coagulation disturbances or is there any therapeutic alternative?
Medical subject headings
- Anticoagulants
- Disseminated Intravascular Coagulation
- Protein C
- Sepsis
- Shock, Septic