Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 22734812.
- Also identified by DOI 10.1111/j.1365-2044.2012.07226.x.
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Abstract
We present the case of a 20-year-old woman who developed rhabdomyolysis, disseminated intravascular coagulopathy and multi-organ failure induced by ecstasy. Following initial improvement, she developed delayed rhabdomyolysis then haloperidol-induced neuroleptic malignant syndrome, which was treated with a total of 50 mg.kg(-1) dantrolene. Subsequent genetic testing revealed a novel potentially pathogenic variant in the ryanodine receptor type 1 gene. However, caffeine-halothane contracture testing of the patient's mother who carried the same gene variant was negative for malignant hyperthermia.
Medical subject headings
- Hallucinogens
- N-Methyl-3,4-methylenedioxyamphetamine
- Neuroleptic Malignant Syndrome
- Rhabdomyolysis
- Ryanodine Receptor Calcium Release Channel