Pharmacology: A false sense of non-self.
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- Record sourced from PubMed, PMID 22739311.
- Also identified by DOI 10.1038/486479a and PMC identifier PMC3013815.
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Abstract
Elucidation of abacavir hypersensitivity syndrome in HIV-1 patients establishes a new pharmacogenetic paradigm. A drug can alter the bodies’ surface display of peptides bound to a given HLA molecule, thereby initiating life threatening T-cell reactions against self-peptides not previously exposed to the immune system.