PurityEst: estimating purity of human tumor samples using next-generation sequencing data.
Level V
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- Record sourced from PubMed, PMID 22743227.
- Also identified by DOI 10.1093/bioinformatics/bts365 and PMC identifier 3426843.
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Abstract
We developed a novel algorithm, PurityEst, to infer the tumor purity level from the allelic differential representation of heterozygous loci with somatic mutations in a human tumor sample with a matched normal tissue using next-generation sequencing data. We applied our tool to a whole cancer genome sequencing datasets and demonstrated the accuracy of PurityEst compared with DNA copy number-based estimation. PurityEst has been implemented in PERL and is available at http://odin.mdacc.tmc.edu/~xsu1/PurityEst.html.
Medical subject headings
- Algorithms
- Models, Genetic
- Neoplasms
- Sequence Analysis, DNA