EP4: a new piece in the fibrotic puzzle.
Level V
Where this comes from
- Record sourced from PubMed, PMID 22743564.
- Also identified by DOI 10.1038/ki.2012.125.
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Abstract
Most progressive and severe acute kidney diseases lead to renal fibrosis, for which we still lack effective treatment options. Prostaglandin E(2) (PGE(2)) is one of the most abundant prostanoids, exerting its pleiotropic functions via four receptors, EP(1) through EP(4). Recent studies indicate that the PGE(2)-EP(4) pathway is a potent endogenous renoprotective system that limits renal fibrosis by acting on multiple cellular targets.
Medical subject headings
- Dinoprostone
- Epithelial Cells
- Kidney Diseases
- Kidney Tubules
- Receptors, Prostaglandin E, EP4 Subtype