Peak mechanical loads induced in the in vitro edge-to-edge repair of posterior leaflet flail.

Abstract

Percutaneous edge-to-edge mitral valve (MV) repair is a potential therapeutic option for patients presenting with mitral regurgitation, who may not be suitable for surgery. We characterized the edge-to-edge repair forces in a posterior leaflet flail MV model to identify potential modes of mechanical failure. Porcine MVs were evaluated in two different sizes (Physio II 32 and 40) in a left-side heart simulator under physiologic hemodynamic conditions. Edge-to-edge repair was simulated by suturing miniature force transducers near the free edge of the anterior and posterior leaflets, on the ventricular side, resulting in a double orifice MV. Posterior leaflet flail was created by selective chordal cutting. Chordal cutting resulted in posterior leaflet flail and mitral regurgitation; all valves coapted normally before chordal cutting. Peak systolic control forces (size 32, 0.098 ± 0.058 N; size 40, 0.236 ± 0.149 N) were not significantly different from systolic flail forces (size 32, 0.136 ± 0.107 N; size 40, 0.220 ± 0.128 N) for either MV size. No correlation was observed between force magnitude and flail height or width. Peak systolic force was greater (p = 0.08) for the larger MVs (size 40 compared with size 32). Finally, peak diastolic force was significantly smaller (p = 0.04) than peak systolic force regardless of valve size. For the first time, forces imparted on an edge-to-edge MV repair were quantified for a posterior leaflet flail model. Force magnitude was not significantly altered with flail compared with control; it was greatest during peak systole and increased with valve size.