Connective tissue disease: SSc-fibrosis takes flight with Wingless inhibition.
Level V
Where this comes from
- Record sourced from PubMed, PMID 22751566.
- Also identified by DOI 10.1038/nrrheum.2012.99 and PMC identifier 3792167.
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Abstract
Recent studies have highlighted a potentially important role for Wnts as profibrotic mediators, and implicated increased Wnt activity in systemic sclerosis and other fibrotic diseases. Strikingly, new data indicates that Wnts have a central role in the profibrotic activity of TGF-β.
Medical subject headings
- Fibrosis
- Scleroderma, Systemic