Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent.
basic_science · Level V
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- Record sourced from PubMed, PMID 22753945.
- Also identified by DOI 10.1093/infdis/jis424 and PMC identifier 4125624.
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Abstract
The current standard to assess pentavalent antimonial (SSG) susceptibility of Leishmania is a laborious in vitro assay of which the result has little clinical value because SSG-resistant parasites are also found in SSG-cured patients. Candidate genetic markers for clinically relevant SSG-resistant parasites identified by full genome sequencing were here validated on a larger set of clinical strains. We show that 3 genomic locations suffice to specifically detect the SSG-resistant parasites found only in patients experiencing SSG treatment failure. This finding allows the development of rapid assays to monitor the emergence and spread of clinically relevant SSG-resistant Leishmania parasites.
Medical subject headings
- Antimony Sodium Gluconate
- Antiprotozoal Agents
- Leishmania donovani
- Leishmaniasis, Visceral