Leptin in the liver: a toxic or beneficial mix?
basic_science · Level V
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- Record sourced from PubMed, PMID 22768831.
- Also identified by DOI 10.1016/j.cmet.2012.06.009 and PMC identifier 3394672.
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Abstract
Although obesity is associated with nonalcoholic fatty liver disease (NAFLD), the causal mechanisms are unclear. In this issue, Imajo et al. (2012) show that, in mice, leptin enhances the effects of bacterial endotoxin, promoting the development of NAFLD.