Maternal-fetal immune tolerance, block by block.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22770210.
- Also identified by DOI 10.1016/j.cell.2012.06.020 and PMC identifier 4061910.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulatory T cells in the enforcement of maternal-fetal immune tolerance.