U1 snRNA rewrites the "script".
basic_science · Level V
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- Record sourced from PubMed, PMID 22770211.
- Also identified by DOI 10.1016/j.cell.2012.06.017 and PMC identifier 4088317.
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Abstract
Expression of eukaryotic mRNAs requires the collaboration of a host of RNA processing factors acting upon the transcript. Berg et al. describe how a pre-mRNA splicing factor modulates the activity of the polyadenylation machinery to regulate mRNA length, with important implications for isoform expression in activated neuronal and immune cells.