Pluripotency takes off without Blimp1.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22770234.
- Also identified by DOI 10.1016/j.stem.2012.06.001 and PMC identifier 3553853.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue of Cell Stem Cell, Bao et al. demonstrate that Blimp1, which is required for primordial germ cell (PGC) specification, is dispensable for the derivation of embryonic stem cells (ESCs), epiblast stem cells (EpiSCs), and reprogramming. These findings argue that the acquisition of pluripotency does not require a Blimp1-dependent PGC intermediate state.