Reprogramming a broken heart.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22770235.
- Also identified by DOI 10.1016/j.stem.2012.06.014.
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Abstract
Fibrosis resulting from cardiac injury presents a major challenge to restoring heart function after myocardial infarction. Two recent papers in Nature report successful in vivo reprogramming of fibroblasts to cardiomyocytes in injured mouse hearts (Qian et al., 2012; Song et al., 2012), resulting in improved cardiac function and reduced scar formation.