An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22770236.
- Also identified by DOI 10.1016/j.stem.2012.06.003 and PMC identifier 3468946.
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Abstract
Identifying well-tolerated, oral medications that enhance adult neurogenesis is of great clinical interest. In this issue of Cell Stem Cell, Wang et al. (2012) demonstrate that the diabetes medication metformin enhances spatial learning in mice by activating the atypical PKC/CBP pathway in adult neural stem cells.
Medical subject headings
- Aging
- Memory
- Metformin
- Neurogenesis