Polycomb in stem cells: PRC1 branches out.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22770239.
- Also identified by DOI 10.1016/j.stem.2012.06.005.
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Abstract
Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this model indicating that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions in embryonic and adult stem cells.
Medical subject headings
- Repressor Proteins
- Stem Cells