You are what you eat: dietary salt intake and renin-angiotensin blockade in diabetic nephropathy.
Where this comes from
- Record sourced from PubMed, PMID 22791321.
- Also identified by DOI 10.1038/ki.2012.148 and PMC identifier 3397395.
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Abstract
Interactions between sodium intake, the renin-angiotensin system, and renal and cardiovascular outcomes are incompletely understood. The analysis by Lambers Heerspink et al. shows that angiotensin receptor blockade improves diabetic nephropathy and cardiovascular disease more when dietary sodium intake is low, and suggests possible harm when sodium intake is high. These findings highlight dietary salt as a modifiable cardiovascular and renal risk factor and emphasize the need for detailed mechanistic studies.
Medical subject headings
- Angiotensin Receptor Antagonists
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Diet, Sodium-Restricted