A neuroendocrine view of ECT.
Level V
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- Record sourced from PubMed, PMID 2279210.
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Abstract
"A neuroendocrine hypothesis to explain the clinical activity of convulsive therapy is described. The hypothesis is based on the diabetes/insulin model and suggests that hypothalamic dysfunction with an insufficiency of a mood-maintaining peptide is the basis for affective disorders. Repeated seizures enhance the production and release of the hypothalamic peptide antidepressin - the active principle that relieves both neuroendocrine and behavioral abnormalities.
Medical subject headings
- Bipolar Disorder
- Brain
- Depressive Disorder
- Electroconvulsive Therapy
- Neuropeptides
- Schizophrenia
- Schizophrenic Psychology