Transcription, splicing, and release: are we there yet?
basic_science · Level V
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- Record sourced from PubMed, PMID 22817885.
- Also identified by DOI 10.1016/j.cell.2012.07.004.
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Abstract
A systematic analysis of LPS-induced gene expression in macrophages by Bhatt et al. demonstrates that inflammatory responses are governed primarily at the level of transcription initiation. Unexpectedly, full-length nascent RNAs that contain introns appear to accumulate on chromatin, presumably to complete processing, prior to release of functional mRNA for export to the cytoplasm.