The split personality of CENP-A nucleosomes.
basic_science · Level V
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- Record sourced from PubMed, PMID 22817887.
- Also identified by DOI 10.1016/j.cell.2012.07.003 and PMC identifier 3724509.
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Abstract
The composition and structure of centromeric nucleosomes, which contain the histone H3 variant CENP-A, is intensely debated. Two independent studies in this issue, in yeast and human cells, now suggest that CENP-A nucleosomes adopt different structures depending on the stage of the cell cycle.