miR-122 regulates hepatic lipid metabolism and tumor suppression.
basic_science · Level V
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- Record sourced from PubMed, PMID 22820284.
- Also identified by DOI 10.1172/JCI63966 and PMC identifier 3408753.
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Abstract
In this issue of JCI, two independent groups describe the effects of germline and liver-specific deletion of Mir122a, the predominant liver miRNA. Their findings reveal a critical role for miR-122 in fat and cholesterol metabolism but suggest that other metabolic actions of the liver are independent of miR-122. Knockout mice also displayed hepatic inflammation, fibrosis, and a high incidence of hepatocellular carcinoma, suggesting that miR-122 has a tumor suppressor role in hepatocytes.