Memory CD4+ T cells: beyond "helper" functions.
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- Record sourced from PubMed, PMID 22820285.
- Also identified by DOI 10.1172/JCI65208 and PMC identifier 3408759.
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Abstract
In influenza virus infection, antibodies, memory CD8+ T cells, and CD4+ T cells have all been shown to mediate immune protection, but how they operate and interact with one another to mediate efficient immune responses against virus infection is not well understood. In this issue of the JCI, McKinstry et al. have identified unique functions of memory CD4+ T cells beyond providing "help" for B cell and CD8+ T cell responses during influenza virus infection.