Targeting PES1 for restoring the ERα/ERβ ratio in breast cancer.
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- Record sourced from PubMed, PMID 22820293.
- Also identified by DOI 10.1172/JCI65133 and PMC identifier 3533503.
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Abstract
Alteration of the ERα/ERβ balance is a critical step in breast cancer development and progression, and selective restoration of the activity of estrogen receptors has been proposed as one of the major therapeutic approaches for breast cancer. In this issue of JCI, Cheng et al. show that, by differentially modulating the stability of ERα and ERβ, PES1 increases the ERα/ERβ ratio and triggers breast tumor growth. These findings highlight PES1 as a potential target for the treatment of breast cancer.