The pre-emptive analgesic effect of a cyclooxygenase-2 inhibitor in a rat model of acute postoperative pain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22823006.
- Also identified by DOI 10.1111/j.1365-2044.2012.07246.x.
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Abstract
We examined the pre-emptive analgesic effect of a cyclooxygenase (COX)-2 inhibitor in a rat surgical pain model and characterised the changes in cutaneous COX-2 around a surgical site. Thermal hyperalgesia and mechanical allodynia were tested in the rats for three days after incision and skin tissues were collected for analysis of COX-2. There was decreased expression of cutaneous COX-2 one day after surgical incision. Pre-incision injection of the COX-2 inhibitor significantly inhibited expression of COX-2 and also reduced thermal hyperalgesia (but not mechanical allodynia) compared with the post-incision COX-2-inhibitor injection group, one day after incision.
Medical subject headings
- Cyclooxygenase 2 Inhibitors
- Pain Management
- Postoperative Pain
- Pyrazoles
- Sulfonamides