Posttranslational modifications of proteins in type 1 diabetes: the next step in finding the cure?
Level V
Where this comes from
- Record sourced from PubMed, PMID 22826307.
- Also identified by DOI 10.2337/db11-1675 and PMC identifier 3402302.
- Licence recorded as CC BY-NC-ND.
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Abstract
The overall role of modification of β-cell antigens in type 1 diabetes has not been elucidated and was the focus of a recent workshop on posttranslational modification of proteins in type 1 diabetes. The prevailing opinion of the workshop attendees was that novel insights into the mechanism of loss of immune tolerance might be gained and that novel diagnostic and therapeutic approaches could be developed for type 1 diabetes if protein modifications were shown to play a critical role in the disease.
Medical subject headings
- Antigens
- Diabetes Mellitus, Type 1
- Insulin-Secreting Cells
- Protein Processing, Post-Translational
- Proteins