Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22842475.
- Also identified by DOI 10.1038/nm.2844.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Pressure-induced vasodilation (PIV) delays the decrease in cutaneous blood flow produced by local application of low pressure to the skin, a physiologically appropriate adjustment of local vasomotor function. Individuals without a normal PIV response have a high risk of ulceration. Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and for protecting against pressure ulcers in mice.
Medical subject headings
- Acid Sensing Ion Channels
- Hyperemia
- Mechanoreceptors
- Pressure Ulcer
- Skin
- Vasodilation