Microparticles and microRNAs of endothelial progenitor cells ameliorate acute kidney injury.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 22846811.
- Also identified by DOI 10.1038/ki.2012.152 and PMC identifier 3410558.
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Abstract
Horizontal information transfer between cells via microparticles is a newly identified communication system. MicroRNAs regulate gene expression and are detected in microparticles. Cantaluppi et al. suggest that microparticles derived from circulating angiogenic cells--'endothelial progenitor cells' (EPCs)--harbor endothelial-protective miRNAs such as miR-126 and that delivery of EPC-derived microparticles during acute kidney ischemia-reperfusion in rats ameliorates kidney dysfunction and damage. We highlight the importance, potential future impact, and limitations of this study.
Medical subject headings
- Acute Kidney Injury
- Cell-Derived Microparticles
- Endothelial Cells
- Kidney
- MicroRNAs
- Reperfusion Injury
- Stem Cell Transplantation
- Stem Cells