Intrarenal urothelial transformation after obstruction: a novel metaplasia.
Level V
Where this comes from
- Record sourced from PubMed, PMID 22846812.
- Also identified by DOI 10.1038/ki.2012.153.
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Abstract
Obstructive nephropathy is a major cause of acute renal failure and end-stage renal disease. We discuss the new findings of Girshovich et al., who show that transformation of intrarenal urothelium into a bladder-like urothelium depends on the activation of the FGF7-FGFR2 signaling pathway following acute ureteral obstruction. A possible link between hypoxia-inducible factor 1α and the FGF-FGFR signaling pathway is suggested.
Medical subject headings
- Cell Differentiation
- Cell Proliferation
- Cell Transdifferentiation
- Kidney
- Ureteral Obstruction
- Urinary Bladder
- Urothelium