Pathological crystallization of human immunoglobulins.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22847421.
- Also identified by DOI 10.1073/pnas.1211723109 and PMC identifier 3421172.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations. This suggests that, even within the regular immune response to infections, cryoprecipitation of Ig can be possible.
Medical subject headings
- Cryoglobulinemia
- Cryoglobulins