Adult neurogenesis: VCAM stems the tide.
editorial · Level V
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- Record sourced from PubMed, PMID 22862936.
- Also identified by DOI 10.1016/j.stem.2012.07.012 and PMC identifier 3437932.
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Abstract
In this issue of Cell Stem Cell, Kokovay et al. uncover that VCAM1 expression in neural stem cells regulates adult neurogenesis. Cerebrospinal fluid-borne IL-1β upregulates VCAM1 expression, which in turn regulates the architecture of the stem cell niche, redox homeostasis, and neurogenesis.